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Allele : Col2a1<tm1(SOX9)Crm> collagen, type II, alpha 1; targeted mutation 1, Benoit de Crombrugghe
Primary Identifier  MGI:3045169 Allele Type  Targeted
Attribute String  Humanized sequence, Inserted expressed sequence Gene  Col2a1
Transmission  Germline Strain of Origin  129S4/SvJae-Tg(Prm-cre)70Og
Is Recombinase  false Is Wild Type  false
molecularNote  A 3xHA-tagged human SOX9 cDNA sequence and floxed neo were inserted upstream of exon 2 by homologous recombination. Transient cre-mediated recombination excised the neo, leaving only the human SOX9 insertion sequence. Northern blot of rib cartilage in heterozygous mutant mice revealed knocked-in SOX9 gene expression was ~20% of that of endogenous Sox9 gene expression.
  • mutations:
  • Insertion
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Trail: Allele

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0 Mutation Involves

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Trail: Allele




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