| First Author | Krieg C | Year | 2007 |
| Journal | Nat Immunol | Volume | 8 |
| Issue | 2 | Pages | 162-71 |
| PubMed ID | 17206146 | Mgi Jnum | J:117859 |
| Mgi Id | MGI:3697926 | Doi | 10.1038/ni1418 |
| Citation | Krieg C, et al. (2007) B and T lymphocyte attenuator regulates CD8(+) T cell-intrinsic homeostasis and memory cell generation. Nat Immunol 8(2):162-71 |
| abstractText | B and T lymphocyte attenuator (BTLA) is a negative regulator of T cell activation, but its function in vivo is not well characterized. Here we show that mice deficient in full-length BTLA or its ligand, herpesvirus entry mediator, had increased number of memory CD8(+) T cells. The memory CD8(+) T cell phenotype resulted from a T cell-intrinsic perturbation of the CD8(+) T cell pool. Naive BTLA-deficient CD8(+) T cells were more efficient than wild-type cells at generating memory in a competitive antigen-specific system. This effect was independent of the initial expansion of the responding antigen-specific T cell population. In addition, BTLA negatively regulated antigen-independent homeostatic expansion of CD4(+) and CD8(+) T cells. These results emphasize two central functions of BTLA in limiting T cell activity in vivo. |
