| First Author | Griffiths KL | Year | 2013 |
| Journal | J Cell Mol Med | Volume | 17 |
| Issue | 12 | Pages | 1608-18 |
| PubMed ID | 24251878 | Mgi Jnum | J:251759 |
| Mgi Id | MGI:6102180 | Doi | 10.1111/jcmm.12174 |
| Citation | Griffiths KL, et al. (2013) Investigation into the prevalence of a novel dendritic-like cell subset in vivo. J Cell Mol Med 17(12):1608-18 |
| abstractText | A novel dendritic-like cell subset termed L-DC was recently identified in murine spleen based on marker expression of a homogeneous cell population derived from long-term culture of neonatal spleen. The function of L-DC is distinct from other splenic dendritic and myeloid cell subsets because of their high endocytic capacity and their ability to cross-present antigen to CD8(+) T cells. This paper shows the subset to be unique to spleen and blood, with a similar, but possibly functionally distinct subset also present in bone marrow. The prevalence of the subset is low; ~6% of all dendritic and myeloid cells in the spleen and ~5% in blood. However, they are a distinct cell type on the basis of marker expression, and endocytic and T-cell stimulatory capacity. Attempts to identify an enriched population of these cells in mutant mouse strains with reported increases in myelopoiesis showed either a lack of L-DC or an altered phenotype reflective of the phenotype of the mouse strain. |
