| First Author | Turner JS | Year | 2018 |
| Journal | Cell Rep | Volume | 25 |
| Issue | 6 | Pages | 1395-1403.e4 |
| PubMed ID | 30403996 | Mgi Jnum | J:270796 |
| Mgi Id | MGI:6278733 | Doi | 10.1016/j.celrep.2018.10.042 |
| Citation | Turner JS, et al. (2018) B Cell Receptor Crosslinking Augments Germinal Center B Cell Selection when T Cell Help Is Limiting. Cell Rep 25(6):1395-1403.e4 |
| abstractText | Antigen-dependent engagement of germinal center (GC) B cell receptors (BCRs) promotes antigen internalization and presentation for follicular helper T cells. However, whether BCR signaling is critical or synergistic with T cell help for GC B cell selection or differentiation is unclear. Here, by adapting an experimental approach that enables independent delivery of BCR-crosslinking antigen or T cell help to GC B cells in vivo, we showed that T cell help was sufficient to induce GC B cell expansion and plasmablast formation. However, although BCR crosslinking could not by itself promote GC B cell selection or differentiation, it could synergize with T cell help to enhance the GC and plasmablast responses when T cell help was limiting. These findings indicate that GC B cells can integrate variable inputs from T cell help and BCR signaling in vivo for an optimal process of selection and differentiation, critical for potent long-term humoral immunity. |
