| First Author | Westritschnig K | Year | 2013 |
| Journal | Mol Immunol | Volume | 53 |
| Issue | 4 | Pages | 379-86 |
| PubMed ID | 23099476 | Mgi Jnum | J:191097 |
| Mgi Id | MGI:5460947 | Doi | 10.1016/j.molimm.2012.09.002 |
| Citation | Westritschnig K, et al. (2013) Antigen processing and presentation by dendritic cells is independent of coronin 1. Mol Immunol 53(4):379-86 |
| abstractText | Coronin 1, which is a member of the evolutionary conserved coronin protein family that is highly expressed in all leukocytes is involved in the activation of the Ca(2+)/calcineurin signaling pathway following cell surface stimulation in T cells, B cells as well as macrophages. Mice deficient for coronin 1 have strongly reduced peripheral T cell numbers as a result of a lack of pro-survival signals for naive T cells. Whether or not impaired antigen processing and presentation in the absence of coronin 1 expression contributes to this reduction of T cell numbers is unknown. We here show that coronin 1-deficient bone marrow-derived dendritic cells develop normally, and that wild type and coronin 1-deficient dendritic cells were equally able to induce antigen-specific proliferation of T cells. Furthermore, upon immunization, in vivo proliferation of adoptively transferred antigen-specific T cells was comparable in wild type and coronin 1-deficient mice. Finally, infection of wild type and coronin 1-deficient dendritic cells with an ovalbumin-expressing Listeria monocytogenes strain induced comparable levels of ovalbumin-specific T cells responses. Together these results suggest that coronin 1 is dispensable for antigen processing and presentation by dendritic cells. |
