| First Author | Qu Y | Year | 2022 |
| Journal | Cell Immunol | Volume | 378 |
| Pages | 104558 | PubMed ID | 35717749 |
| Mgi Jnum | J:328292 | Mgi Id | MGI:7326856 |
| Doi | 10.1016/j.cellimm.2022.104558 | Citation | Qu Y, et al. (2022) Dectin-2 promotes house dust mite-skewed Th2 response through the activation of cDC2s. Cell Immunol 378:104558 |
| abstractText | The role of Dectin-2 (gene symbol, Clec4n) in house dust mite (HDM) induced Th2 immune response and the exact mechanism remains controversial. In this study, we illustrated that, Clec4n(-/-) mice had decreased Th2 immune response following HDM challenge, which may ascribe to dramatically reduced type 2 conventional dendritic cells (cDC2s) in lung of Clec4n(-/-) mice, as cDC2s from lung of Clec4n(-/-) mice after challenging had less ability to induce Th2 response with decreased production of IL-4/IL-13. Further in vitro experiments showed the activation of Clec4n(-/-)-BMDCs significantly decreased after HDM stimulation accompanied with decreased activation of Syk-NF-kappaB and Syk-JNK signal pathway. Importantly, Dectin-2 expression in PBMCs from asthmatic patients was significantly higher than that in healthy controls. Taken together, these results demonstrated that Dectin-2 could promote cDC2s activation in lung, which polarizes Th2 immune response outlining a novel mechanism of asthma development. |
