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Allele : Kit<tm3Ber> KIT proto-oncogene receptor tyrosine kinase; targeted mutation 3, Alan Bernstein

Primary Identifier	MGI:3045803	Allele Type	Targeted
Gene	Kit	Transmission	Germline
Strain of Origin	(129X1/SvJ x 129S1/Sv)F1-Kitl<+>	Is Recombinase	false
Is Wild Type	false

molecularNote

Two point mutations were inserted into the juxtamembrane (Jx) domain in exon 11: Y567F and Y569F. A floxed neo was excised from intron 14 by transient cre-mediated recombination. Southern blot analysis confirmed recombination.

mutations:
Nucleotide substitutions

cellLines:
Not Specified

synonyms:
Kit<FF>,
Kit<FF>

earliestPublication:
Kimura Y, et al. (2004) Targeted mutations of the juxtamembrane tyrosines in the Kit receptor tyrosine kinase selectively affect multiple cell lineages. Proc Natl Acad Sci U S A 101(16):6015-20

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

0 Carried By

0 Driven By

4 Publication categories

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