| First Author | Lantz O | Year | 2000 |
| Journal | Nat Immunol | Volume | 1 |
| Issue | 1 | Pages | 54-8 |
| PubMed ID | 10881175 | Mgi Jnum | J:90556 |
| Mgi Id | MGI:3044141 | Doi | 10.1038/76917 |
| Citation | Lantz O, et al. (2000) Gamma chain required for naive CD4+ T cell survival but not for antigen proliferation. Nat Immunol 1(1):54-8 |
| abstractText | Lymphoid homeostasis is required to ensure immune responsiveness and to prevent immunodeficiency. As such, the immune system must maintain distinct populations of naive T cells that are able to respond to new antigens as well as memory T cells specific to those antigens it has already encountered. Though both naive and memory T cells reside in and traffic through secondary lymphoid organs, there is growing evidence that the two populations may be regulated differently. We show here that naive T cell survival and memory T cell survival have different requirements for cytokines (including the interleukins IL-2, IL-4, IL-7, IL-9 and IL-15) that use the common cytokine receptor gamma chain (gamma c). Using monoclonal populations of antigen-specific CD4+ T cells, we found that naive T cells cannot survive without gamma c, whereas memory T cells show no such requirement. In contrast, neither naive nor gamma c-deficient memory T cells were impaired in their ability to proliferate and produce cytokines in response to in vivo antigenic stimulation. These data call into question the physiological role of gamma c-dependent cytokines as T cell growth factors and show that naive and memory CD4+ T cell survival is maintained by distinct mechanisms. |
