| Primary Identifier | MGI:3045963 | Allele Type | Chemically induced (ENU) |
| Attribute String | Hypomorph | Gene | Card11 |
| Strain of Origin | C57BL/6JSfdAnu | Is Recombinase | false |
| Is Wild Type | false | Project Collection | APF ENU Mutagenesis |
| molecularNote | Sequencing revealed a T to A transversion that resulted in a leucine to glutamine substitution in a segment predicted to form a coiled coil (CC) domain, and is conserved in the heptad repeats of the predicted alpha-helical coil. Western blot revealed normal levels of protein in mutant B cells. The change from nonpolar leucine to polar glutamine putatively disrupts the CC structure and interferes with protein pairing. |
