| First Author | Ding I | Year | 1999 |
| Journal | Eur J Immunol | Volume | 29 |
| Issue | 12 | Pages | 3956-61 |
| PubMed ID | 10602004 | Mgi Jnum | J:58712 |
| Mgi Id | MGI:1349511 | Doi | 10.1002/(SICI)1521-4141(199912)29:12<3956::AID-IMMU3956>3.0.CO;2-G |
| Citation | Ding I, et al. (1999) Biochemical and functional analysis of mice deficient in expression of the CD45-associated phosphoprotein LPAP. Eur J Immunol 29(12):3956-61 |
| abstractText | The role of the CD45-associated phosphoprotein (LPAP / CD45-AP) during an immune response remains unclear. To understand better the function of LPAP we generated LPAP-deficient mice by disrupting exon 2 of the LPAP gene. LPAP-null mice were healthy and did not show gross abnormalities compared to their wild-type littermates. However, immunofluorescence analysis of T and B lymphocytes revealed a reduced expression of CD45, which did not affect a particular subpopulation. In contrast to a recent report (Matsuda et al., J. Exp. Med. 1998. 187: 1863 - 1870) we neither observed significant alterations of the assembly of the CD45 / lck-complex nor of polyclonal T-cell responses. However, lymphnodes from LPAP-null mice showed increased cellularity, which could indicate that expression of LPAP might be required to prevent expansion of lymphocytes in particular lymphatic organs rather than potentiating immune responses. |
