| First Author | Carlson CM | Year | 2006 |
| Journal | Nature | Volume | 442 |
| Issue | 7100 | Pages | 299-302 |
| PubMed ID | 16855590 | Mgi Jnum | J:111389 |
| Mgi Id | MGI:3653942 | Doi | 10.1038/nature04882 |
| Citation | Carlson CM, et al. (2006) Kruppel-like factor 2 regulates thymocyte and T-cell migration. Nature 442(7100):299-302 |
| abstractText | Mammalian Kruppel-like transcription factors are implicated in regulating terminal differentiation of several tissue types. Deficiency in Kruppel-like factor (KLF) 2 (also known as LKLF) leads to a massive loss of the peripheral T-cell pool, suggesting KLF2 regulates T-cell quiescence and survival. Here we show, however, that KLF2 is essential for T-cell trafficking. KLF2-deficient (Klf2-/-) thymocytes show impaired expression of several receptors required for thymocyte emigration and peripheral trafficking, including the sphingosine-1-phosphate (S1P) receptor S1P1, CD62L and beta7 integrin. Furthermore, KLF2 both binds and transactivates the promoter for S1P1--a receptor that is critical for thymocyte egress and recirculation through peripheral lymphoid organs. Our findings suggest that KLF2 serves to license mature T cells for trafficking from the thymus and recirculation through secondary lymphoid tissues. |
