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Allele : Cacna1c<tm1Jst> calcium channel, voltage-dependent, L type, alpha 1C subunit; targeted mutation 1, Jorg Striessnig

Primary Identifier  MGI:3047071 Allele Type  Targeted
Attribute String  Not Specified Gene  Cacna1c
Transmission  Germline Strain of Origin  (129X1/SvJ x 129S1/Sv)F1-Kitl<+>
Is Recombinase  false Is Wild Type  false
molecularNote  A floxed neo was inserted upstream of a mutagenized exon 24 containing T1066Y, that encodes regions of the alpha 1 subunit. Crossing with deleter mice excised the floxed neo in the germ line, leaving the mutation in exon 24. Southern blot confirmed recombination and Western blot of brain and heart membranes showed no affects of the mutation on gene expression density.
  • mutations:
  • Nucleotide substitutions,
  • Insertion
  • synonyms:
  • Cav1.2DHP<->,
  • Cav1.2DHP<->
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

0 Carried By

0 Driven By

13 Publication categories