| Primary Identifier | MGI:3047539 | Allele Type | Targeted |
| Attribute String | Null/knockout | Gene | Cd79a |
| Transmission | Germline | Strain of Origin | 129P2/OlaHsd |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | Crossing Cd79atm5Cgn mice with deleter mice expressing cre in the germline created this allele in which floxed exon 4 was excised, thereby eliminating the membrane-proximal part of the cytoplasmic tail and disrupting the ITAM motif. Flow cytometry revealed severely impaired B cell development, with bone marrow numbers of immature and mature B cells being about 10 and 100 times lower than in wild-type controls. |
