| First Author | Roychoudhuri R | Year | 2016 |
| Journal | Nat Immunol | Volume | 17 |
| Issue | 7 | Pages | 851-860 |
| PubMed ID | 27158840 | Mgi Jnum | J:259445 |
| Mgi Id | MGI:6142857 | Doi | 10.1038/ni.3441 |
| Citation | Roychoudhuri R, et al. (2016) BACH2 regulates CD8(+) T cell differentiation by controlling access of AP-1 factors to enhancers. Nat Immunol 17(7):851-860 |
| abstractText | T cell antigen receptor (TCR) signaling drives distinct responses depending on the differentiation state and context of CD8(+) T cells. We hypothesized that access of signal-dependent transcription factors (TFs) to enhancers is dynamically regulated to shape transcriptional responses to TCR signaling. We found that the TF BACH2 restrains terminal differentiation to enable generation of long-lived memory cells and protective immunity after viral infection. BACH2 was recruited to enhancers, where it limited expression of TCR-driven genes by attenuating the availability of activator protein-1 (AP-1) sites to Jun family signal-dependent TFs. In naive cells, this prevented TCR-driven induction of genes associated with terminal differentiation. Upon effector differentiation, reduced expression of BACH2 and its phosphorylation enabled unrestrained induction of TCR-driven effector programs. |
