| First Author | Greenberg MV | Year | 2017 |
| Journal | Nat Genet | Volume | 49 |
| Issue | 1 | Pages | 110-118 |
| PubMed ID | 27841881 | Mgi Jnum | J:261327 |
| Mgi Id | MGI:6151717 | Doi | 10.1038/ng.3718 |
| Citation | Greenberg MV, et al. (2017) Transient transcription in the early embryo sets an epigenetic state that programs postnatal growth. Nat Genet 49(1):110-118 |
| abstractText | The potential for early embryonic events to program epigenetic states that influence adult physiology remains an important question in health and development. Using the imprinted Zdbf2 locus as a paradigm for the early programming of phenotypes, we demonstrate here that chromatin changes that occur in the pluripotent embryo can be dispensable for embryogenesis but instead signal essential regulatory information in the adult. The Liz (long isoform of Zdbf2) transcript is transiently expressed in early embryos and embryonic stem cells (ESCs). This transcription locally promotes de novo DNA methylation upstream of the Zdbf2 promoter, which antagonizes Polycomb-mediated repression of Zdbf2. Strikingly, mouse embryos deficient for Liz develop normally but fail to activate Zdbf2 in the postnatal brain and show indelible growth reduction, implying a crucial role for a Liz-dependent epigenetic switch. This work provides evidence that transcription during an early embryonic timeframe can program a stable epigenetic state with later physiological consequences. |
