Primary Identifier | MGI:3047834 | Allele Type | Targeted |
Attribute String | Null/knockout | Gene | Dnmt3b |
Transmission | Germline | Strain of Origin | 129S4/SvJae |
Is Recombinase | false | Is Wild Type | false |
molecularNote | This allele was created by crossing Dnmt3btm5.1Enl with TNAP-cre mice, thereby excising the floxed segment, which includes exon 19, in the germline. This results in out-of-frame splicing of the mRNAs encoding all three active forms of the protein. |