| First Author | Hattori K | Year | 2016 |
| Journal | Nat Commun | Volume | 7 |
| Pages | 11158 | PubMed ID | 27045525 |
| Mgi Jnum | J:236904 | Mgi Id | MGI:5810060 |
| Doi | 10.1038/ncomms11158 | Citation | Hattori K, et al. (2016) ASK1 signalling regulates brown and beige adipocyte function. Nat Commun 7:11158 |
| abstractText | Recent studies suggest that adult humans have active brown or beige adipocytes, the activation of which might be a therapeutic strategy for the treatment of diverse metabolic diseases. Here we show that the protein kinase ASK1 regulates brown and beige adipocytes function. In brown or white adipocytes, the PKA-ASK1-p38 axis is activated in response to cAMP signalling and contributes to the cell-autonomous induction of genes, including Ucp1. Global and fat-specific ASK1 deficiency leads to impaired metabolic responses, including thermogenesis and oxygen consumption, at the cell and whole-body levels, respectively. Our data thus indicate that the ASK1 signalling axis is a regulator of brown and beige adipocyte gene expression and function. |
