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Allele : Prnd<tm1Aag> prion like protein doppel; targeted mutation 1, Adriano Aguzzi

Primary Identifier	MGI:3047561	Allele Type	Targeted
Attribute String	Null/knockout	Gene	Prnd
Transmission	Germline	Strain of Origin	129P2/OlaHsd
Is Recombinase	false	Is Wild Type	false

molecularNote

The entire open reading frame was replaced with a floxed neo cassette via homologous recombination. RT-PCR and western blot analysis confirmed the absence of RNA and protein expression in homozygous mutants.

mutations:
Intragenic deletion,
Insertion

cellLines:
Not Specified

synonyms:
Prnd<neo>,
Prnd<neo>

earliestPublication:
Behrens A, et al. (2001) Normal neurogenesis and scrapie pathogenesis in neural grafts lacking the prion protein homologue Doppel. EMBO Rep 2(4):347-52

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

1 Carried By

0 Driven By

8 Publication categories

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