Primary Identifier | MGI:3050216 | Allele Type | Targeted |
Attribute String | Recombinase | Gene | Pax8 |
Transmission | Germline | Strain of Origin | 129P2/OlaHsd |
Is Recombinase | true | Is Wild Type | false |
molecularNote | Crossing Pax8tm1(cre)Mbu with mice expressing FLP recombinase in the germline created this allele in which the frt-flanked neo downstream of the inserted Cre was excised, allowing Cre to be expressed. Expression of cre recombinase was detected in the known Pax8 expression domains; in addition, expression was detected in the adrenal gland, and in the facial, vestibulocochlear and cuneate nerves. |