| First Author | Nguyen TH | Year | 2022 |
| Journal | Stem Cell Reports | Volume | 17 |
| Issue | 10 | Pages | 2303-2317 |
| PubMed ID | 36084638 | Mgi Jnum | J:329898 |
| Mgi Id | MGI:7355716 | Doi | 10.1016/j.stemcr.2022.08.004 |
| Citation | Nguyen TH, et al. (2022) Frizzled-6 promotes hematopoietic stem/progenitor cell mobilization and survival during LPS-induced emergency myelopoiesis. Stem Cell Reports 17(10):2303-2317 |
| abstractText | Emergency hematopoiesis involves the activation of bone marrow hematopoietic stem/progenitor cells (HSPCs) in response to systemic inflammation by a combination of cell-autonomous and stroma-dependent signals and leads to their release from bone marrow and migration to periphery. We have previously shown that FZD6 plays a pivotal role in regulating HSPC expansion and long-term maintenance. Now we sought to better understand the underlying mechanisms. Using lipopolysaccharide (LPS)-induced emergency granulopoiesis as a model, we show that failed expansion was intrinsic to FZD6-deficient HSPCs but also required a FZD6-deficient environment. FZD6-deficient HSPCs became more strongly activated, but their mobilization to peripheral blood was impaired and they were more susceptible to inflammatory cell death, leading to enhanced release of pro-inflammatory cytokines in the marrow. These studies indicate that FZD6 has a protective effect in the bone marrow to prevent an overactive inflammatory response and further suggest that mobilization improves HSPC survival during bone marrow inflammation. |
