| First Author | Pauken KE | Year | 2020 |
| Journal | Cell Rep | Volume | 31 |
| Issue | 13 | Pages | 107827 |
| PubMed ID | 32610128 | Mgi Jnum | J:300868 |
| Mgi Id | MGI:6489103 | Doi | 10.1016/j.celrep.2020.107827 |
| Citation | Pauken KE, et al. (2020) The PD-1 Pathway Regulates Development and Function of Memory CD8(+) T Cells following Respiratory Viral Infection. Cell Rep 31(13):107827 |
| abstractText | The PD-1 pathway regulates dysfunctional T cells in chronic infection and cancer, but the role of this pathway during acute infection remains less clear. Here, we demonstrate that PD-1 signals are needed for optimal memory. Mice deficient in the PD-1 pathway exhibit impaired CD8(+) T cell memory following acute influenza infection, including reduced virus-specific CD8(+) T cell numbers and compromised recall responses. PD-1 blockade during priming leads to similar differences early post-infection but without the defect in memory formation, suggesting that timing and/or duration of PD-1 blockade could be tailored to modulate host responses. Our studies reveal a role for PD-1 as an integrator of CD8(+) T cell signals that promotes CD8(+) T cell memory formation and suggest PD-1 continues to fine-tune CD8(+) T cells after they migrate into non-lymphoid tissues. These findings have important implications for PD-1-based immunotherapy, in which PD-1 inhibition may influence memory responses in patients. |
