| First Author | Choi BK | Year | 2018 |
| Journal | Eur J Immunol | Volume | 48 |
| Issue | 10 | Pages | 1739-1749 |
| PubMed ID | 30138536 | Mgi Jnum | J:266480 |
| Mgi Id | MGI:6201506 | Doi | 10.1002/eji.201847633 |
| Citation | Choi BK, et al. (2018) RELT negatively regulates the early phase of the T-cell response in mice. Eur J Immunol 48(10):1739-1749 |
| abstractText | RELT (tumor necrosis factor receptor superfamily member 19-like, TNFRSF19L) is a TNFR superfamily member that is primarily expressed in immune cells and lymphoid tissues, but whose immunological function is not well-defined. Here, we show that RELT is expressed by naive T cells and DCs, and their activation or maturation decreases RELT expression. Using RELT knockout (RELT(-/-) ) mice, we demonstrate that RELT deficiency selectively promotes the homeostatic proliferation of CD4(+) T cells but not CD8(+) T cells, and enhances anti-tumor CD8(+) T-cell responses. We also demonstrate, using an adoptive transfer model in which RELT is knocked-out in either the transferred transgenic CD8(+) T cells or the recipient melanoma-bearing mice, that RELT on multiple immune cells limits the hyper-response of tumor-specific CD8(+) T cells. Hyper-responsiveness of RELT-deficient T cells was induced by promoting their proliferation. Taken together, our findings suggest that RELT acts as a negative regulator that controls the early phase of T-cell activation probably by promoting T-cell apoptosis. |
