| First Author | Barron T | Year | 2019 |
| Journal | Glia | Volume | 67 |
| Issue | 10 | Pages | 1922-1932 |
| PubMed ID | 31313856 | Mgi Jnum | J:279775 |
| Mgi Id | MGI:6343472 | Doi | 10.1002/glia.23670 |
| Citation | Barron T, et al. (2019) Neuronal input triggers Ca(2+) influx through AMPA receptors and voltage-gated Ca(2+) channels in oligodendrocytes. Glia 67(10):1922-1932 |
| abstractText | Communication between neurons and developing oligodendrocytes (OLs) leading to OL Ca(2+) rise is critical for axon myelination and OL development. Here, we investigate signaling factors and sources of Ca(2+) rise in OLs in the mouse brainstem. Glutamate puff or axon fiber stimulation induces a Ca(2+) rise in pre-myelinating OLs, which is primarily mediated by Ca(2+) -permeable AMPA receptors. During glutamate application, inward currents via AMPA receptors and elevated extracellular K(+) caused by increased neuronal activity collectively lead to OL depolarization, triggering Ca(2+) influx via P/Q- and L-type voltage-gated Ca(2+) (Cav ) channels. Thus, glutamate is a key signaling factor in dynamic communication between neurons and OLs that triggers Ca(2+) transients via AMPARs and Cav channels in developing OLs. The results provide a mechanism for OL Ca(2+) dynamics in response to neuronal input, which has implications for OL development and myelination. |
