| First Author | Câmara J | Year | 2009 |
| Journal | J Cell Biol | Volume | 185 |
| Issue | 4 | Pages | 699-712 |
| PubMed ID | 19451276 | Mgi Jnum | J:163219 |
| Mgi Id | MGI:4821248 | Doi | 10.1083/jcb.200807010 |
| Citation | Camara J, et al. (2009) Integrin-mediated axoglial interactions initiate myelination in the central nervous system. J Cell Biol 185(4):699-712 |
| abstractText | All but the smallest-diameter axons in the central nervous system are myelinated, but the signals that initiate myelination are unknown. Our prior work has shown that integrin signaling forms part of the cell-cell interactions that ensure only those oligodendrocytes contacting axons survive. Here, therefore, we have asked whether integrins regulate the interactions that lead to myelination. Using homologous recombination to insert a single-copy transgene into the hypoxanthine phosphoribosyl transferase (hprt) locus, we find that mice expressing a dominant-negative beta1 integrin in myelinating oligodendrocytes require a larger axon diameter to initiate timely myelination. Mice with a conditional deletion of focal adhesion kinase (a signaling molecule activated by integrins) exhibit a similar phenotype. Conversely, transgenic mice expressing dominant-negative beta3 integrin in oligodendrocytes display no myelination abnormalities. We conclude that beta1 integrin plays a key role in the axoglial interactions that sense axon size and initiate myelination, such that loss of integrin signaling leads to a delay in myelination of small-diameter axons. |
