| First Author | Weston MC | Year | 2011 |
| Journal | Neuron | Volume | 69 |
| Issue | 6 | Pages | 1147-59 |
| PubMed ID | 21435559 | Mgi Jnum | J:174729 |
| Mgi Id | MGI:5140672 | Doi | 10.1016/j.neuron.2011.02.002 |
| Citation | Weston MC, et al. (2011) Interplay between VGLUT isoforms and endophilin A1 regulates neurotransmitter release and short-term plasticity. Neuron 69(6):1147-59 |
| abstractText | Vesicular glutamate transporters (VGLUTs) are essential for filling synaptic vesicles with glutamate and mammals express three VGLUT isoforms (VGLUT1-3) with distinct spatiotemporal expression patterns. Here, we find that neurons expressing VGLUT1 have lower release probability and less short-term depression than neurons expressing VGLUT2 or VGLUT3. Investigation of the underlying mechanism identified endophilin A1 as a positive regulator of exocytosis whose expression levels are positively correlated with release efficiency and showed that the differences in release efficiency between VGLUT1- and VGLUT2-expressing neurons are due to VGLUT1's ability to bind endophilin A1 and inhibit endophilin-induced enhancement of release probability. |
