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Allele : Sox2<tm3Skn> SRY (sex determining region Y)-box 2; targeted mutation 3, Silvia K Nicolis

Primary Identifier	MGI:3052123	Allele Type	Targeted
Attribute String	Null/knockout	Gene	Sox2
Transmission	Germline	Strain of Origin	129S1/Sv-Oca2<+> Tyr<+> Kitl<+>
Is Recombinase	false	Is Wild Type	false

molecularNote

A floxed PGK-neo replaced an upstream neural cell-specific enhancer. Crossing with CMV-Cre mice excised the floxed neo, leaving a single loxP site.

mutations:
Intragenic deletion,
Insertion

cellLines:
Not Specified

synonyms:
Sox2<deltaENHdeltaneo>,
Sox2<deltaENHdeltaneo>

earliestPublication:
Ferri AL, et al. (2004) Sox2 deficiency causes neurodegeneration and impaired neurogenesis in the adult mouse brain. Development 131(15):3805-19

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

1 Carried By

0 Driven By

6 Publication categories

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