| First Author | Fehling HJ | Year | 1995 |
| Journal | Nature | Volume | 375 |
| Issue | 6534 | Pages | 795-8 |
| PubMed ID | 7596413 | Mgi Jnum | J:26493 |
| Mgi Id | MGI:73939 | Doi | 10.1038/375795a0 |
| Citation | Fehling HJ, et al. (1995) Crucial role of the pre-T-cell receptor alpha gene in development of alpha beta but not gamma delta T cells. Nature 375(6534):795-8 |
| abstractText | In T-cell precursors, the T-cell-receptor beta chain is expressed before the T-cell-receptor alpha chain and is sufficient to advance T-cell development in the absence of T-cell receptor alpha chains. In immature T cells, the T-cell-receptor beta protein can form disulphide-linked heterodimers with the pre-T-cell-receptor alpha chain and associate with signal-transducing CD3 molecules. The recently cloned pre-T-cell-receptor alpha gene encodes a transmembrane protein that is expressed in immature but not mature T cells. Here we show that alpha beta, but not gamma delta, cell development is severely hampered in pre-T-cell-receptor alpha-gene-deficient mice, which establishes a crucial role for the pre-T-cell receptor in early thymocyte development. |
