| First Author | Aifantis I | Year | 1998 |
| Journal | Immunity | Volume | 9 |
| Issue | 5 | Pages | 649-55 |
| PubMed ID | 9846486 | Mgi Jnum | J:51338 |
| Mgi Id | MGI:1315115 | Doi | 10.1016/s1074-7613(00)80662-7 |
| Citation | Aifantis I, et al. (1998) On the role of the pre-T cell receptor in alphabeta versus gammadelta T lineage commitment. Immunity 9(5):649-55 |
| abstractText | The role of the pre-T cell receptor (TCR) in lineage commitment to the gammadelta versus alphabeta lineage of T cells was addressed by analyzing TCRbeta chain rearrangements in gammadelta T cells from wild-type and pre-TCR-deficient mice by single cell polymerase chain reaction. Results show that the pre-TCR selects against gammadelta T cells containing rearranged Vbeta genes and that gammadelta T cell precursors but not gammadelta T cells express the pre-TCRalpha protein. Furthermore, pre-TCR-induced proliferation could not be detected in gammadelta T cells. We propose that the pre-TCR commits developing T cells to the alphabeta lineage by an instructive mechanism that has largely replaced an evolutionary more ancient stochastic mechanism of lineage commitment. |
