| First Author | Gurusamy N | Year | 2010 |
| Journal | FEBS Lett | Volume | 584 |
| Issue | 1 | Pages | 187-93 |
| PubMed ID | 19931534 | Mgi Jnum | J:155545 |
| Mgi Id | MGI:4414706 | Doi | 10.1016/j.febslet.2009.11.054 |
| Citation | Gurusamy N, et al. (2010) Downregulation of cardiac lineage protein-1 confers cardioprotection through the upregulation of redox effectors. FEBS Lett 584(1):187-93 |
| abstractText | CLP-1, the mouse homologue of human Hexim1 protein, exerts inhibitory control on transcriptional elongation factor-b of RNA transcript elongation. Previously, we have demonstrated that downregulation of cardiac lineage protein-1 (CLP-1) in CLP-1(+/-) heterozygous mice affords cardioprotection against ischemia-reperfusion injury. Our current study results show that the improvement in cardiac function in CLP-1(+/-) mice after ischemia-reperfusion injury is achieved through the potentiation of redox signaling and their molecular targets including redox effector factor-1, nuclear factor erythroid 2-related factor, and NADPH oxidase 4 and the active usage of thioredoxin-1, thioredoxin-2, glutaredoxin-1 and glutaredoxin-2. Our results suggest that drugs designed to down regulate CLP-1 could confer cardioprotection through the potentiation of redox cycling. |
