| First Author | Schultz JR | Year | 1993 |
| Journal | Nature | Volume | 365 |
| Issue | 6448 | Pages | 762-4 |
| PubMed ID | 8413656 | Mgi Jnum | J:129704 |
| Mgi Id | MGI:3770000 | Doi | 10.1038/365762a0 |
| Citation | Schultz JR, et al. (1993) Protein composition determines the anti-atherogenic properties of HDL in transgenic mice. Nature 365(6448):762-4 |
| abstractText | High-density lipoprotein (HDL) contains two major proteins, apolipoprotein A-I (apoA-I) and apolipoprotein A-II (apoA-II), comprising about 70% and 20% of the total HDL protein mass, respectively. HDL exists in human plasma in two main forms, one containing apoA-I with apoA-II (AI/AII-HDL) and another containing apoA-I without apoA-II (AI-HDL). A strong inverse relationship exists between total plasma HDL concentration and atherosclerosis, but the results of studies examining the relationship between AI-HDL and AI/AII-HDL and atherosclerosis have been conflicting. To determine whether these two HDL populations have different effects on atherogenesis, human apoA-I (AI) and human apoA-I and apoA-II (AI/AII) transgenic mice were produced in an atherosclerosis-susceptible strain. Following an atherogenic diet, despite similar total cholesterol and HDL cholesterol concentrations, the area of atherogenic lesions in the AI/AII mice was 15-fold greater than in the AI animals. These studies show that the protein composition of HDL significantly affects its role in atherogenesis and that AI-HDL is more antiatherogenic than AI/AII-HDL. |
