| Primary Identifier | MGI:3052743 | Allele Type | Targeted |
| Attribute String | Constitutively active | Gene | Foxo1 |
| Transmission | Germline | Strain of Origin | Not Specified |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | The 5' UTR and the first 208 codons of exon 1, encoding the N-terminal half of the forkhead domain, were replaced with a targeting vector containing a floxed PGK-neo and FOXO1a cDNA, encoding a constitutively active form of the protein. RT-PCR and Western blot showed lack of wild-type transcript and protein, respectively, in mutant embryos. |
