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Allele : Fgfr2<tm4Lni> fibroblast growth factor receptor 2; targeted mutation 4, Peter Lonai

Primary Identifier	MGI:3053095	Allele Type	Targeted
Attribute String	Humanized sequence	Gene	Fgfr2
Transmission	Germline	Strain of Origin	Not Specified
Is Recombinase	false	Is Wild Type	false

description	Phenotypic Similarity to Human Syndrome: Craniosynostosis J: 235329.
molecularNote	A C342Y replacement was inserted into exon 9 (the IIIc exon) and a floxed neo into intron 9. Mating with mice expressing cre in the germ line excised the floxed neo.

mutations:
Nucleotide substitutions

cellLines:
Not Specified

synonyms:
Fgfr2c<C342Y>,
Fgfr2c<C342Y>

earliestPublication:
Eswarakumar VP, et al. (2004) A gain-of-function mutation of Fgfr2c demonstrates the roles of this receptor variant in osteogenesis. Proc Natl Acad Sci U S A 101(34):12555-60

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

2 Carried By

0 Driven By

20 Publication categories

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