Primary Identifier | MGI:3053096 | Allele Type | Targeted |
Attribute String | Recombinase | Gene | Scn10a |
Transmission | Germline | Strain of Origin | 129 |
Is Recombinase | true | Is Wild Type | false |
molecularNote | Cre recombinase, 3' UTR of Scn10a, and an FRT flanked neo were knocked into the initiator methionine so that Cre replaced the ATG. Crossing with mice expressing Flp recombinase in the germ line excised the floxed neo. Cre expression was observed beginning at embryonic day 14 in small-diameter neurons in dorsal root, trigeminal, and nodose ganglia but absent in nonneuronal and CNS tissues. |