| First Author | Mansuy-Aubert V | Year | 2015 |
| Journal | Elife | Volume | 4 |
| PubMed ID | 26076474 | Mgi Jnum | J:269509 |
| Mgi Id | MGI:6208413 | Doi | 10.7554/eLife.06667 |
| Citation | Mansuy-Aubert V, et al. (2015) Loss of the liver X receptor LXRalpha/beta in peripheral sensory neurons modifies energy expenditure. Elife 4 |
| abstractText | Peripheral neural sensory mechanisms play a crucial role in metabolic regulation but less is known about the mechanisms underlying vagal sensing itself. Recently, we identified an enrichment of liver X receptor alpha and beta (LXRalpha/beta) in the nodose ganglia of the vagus nerve. In this study, we show mice lacking LXRalpha/beta in peripheral sensory neurons have increased energy expenditure and weight loss when fed a Western diet (WD). Our findings suggest that the ability to metabolize and sense cholesterol and/or fatty acids in peripheral neurons is an important requirement for physiological adaptations to WDs. |
