| Primary Identifier | MGI:3052812 | Allele Type | Targeted |
| Attribute String | Inducible, Recombinase | Gene | Alb |
| Transmission | Germline | Strain of Origin | 129S2/SvPas |
| Induced With | tamoxifen | Is Recombinase | true |
| Is Wild Type | false |
| molecularNote | A vector was used to insert IRES-Cre-ERT2 downstream of the stop codon in exon 14. Transient FLP-recombinase excised a FRT-floxed neo 3' to the Cre. ES cell clone XF136.64 was injected into blastocysts to generated mice. Southern blot confirmed recombination. RT-PCR indicated bicistronic expression was only present in the liver of mutants. Immunohistochemical analysis of liver using an anti-Cre antibody showed that Cre is expressed in most, if not all, hepatocytes. |
