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Allele : Alb<tm1(cre/ERT2)Mtz> albumin; targeted mutation 1, Daniel Metzger
Primary Identifier  MGI:3052812 Allele Type  Targeted
Attribute String  Inducible, Recombinase Gene  Alb
Transmission  Germline Strain of Origin  129S2/SvPas
Induced With  tamoxifen Is Recombinase  true
Is Wild Type  false
molecularNote  A vector was used to insert IRES-Cre-ERT2 downstream of the stop codon in exon 14. Transient FLP-recombinase excised a FRT-floxed neo 3' to the Cre. ES cell clone XF136.64 was injected into blastocysts to generated mice. Southern blot confirmed recombination. RT-PCR indicated bicistronic expression was only present in the liver of mutants. Immunohistochemical analysis of liver using an anti-Cre antibody showed that Cre is expressed in most, if not all, hepatocytes.
  • mutations:
  • Insertion
  • synonyms:
  • Albumin-CreER,
  • Alb<tm1(cre/ESR1)Mtz>,
  • Alb-CreERT2,
  • SA<Cre-ERT2>,
  • SA-CRE-ER<T2>,
  • Albumin-CreER,
  • Alb<ICE>,
  • AlbCre-ERT2<ki>,
  • Alb-CreERT2,
  • SA<Cre-ERT2>,
  • Alb<tm1(cre/ESR1)Mtz>,
  • SA-CRE-ER<T2>,
  • AlbCre-ERT2<ki>,
  • Alb<ICE>
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1 Feature

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0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

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1 Driven By

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Trail: Allele




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