| Primary Identifier | MGI:3053111 | Allele Type | Transgenic |
| Attribute String | Inserted expressed sequence | Gene | Tg(tetFosb)4468Nes |
| Strain of Origin | (SJL x C57BL/6)F1 | Is Recombinase | false |
| Is Wild Type | false |
| description | Homozygous transgenic mice are viable and fertile. These mice express a truncated variant of the Fosb transcription factor. The expressed variant is a highly stable isoform found to be induced in the brain (nucleus accumbens) with repeated exposure to commonly abused drugs, such as amphetamine, morphine, nicotine, and phencyclidine. Transcription is directed by a tetracycline-responsive promoter element (TRE). In bitransgenic mice produced by breeding a mouse carrying this transgene with a transgenic mouse expressing tetracycline-controlled transactivator protein (tTA), Fosb expression can be negatively regulated with the tetracycline analog, doxycycline. |
| molecularNote | The transgene contains a Fosb cDNA under the control of a tetracycline-regulated promoter, an SV40 intron, and a poly A signal sequence. |
