Primary Identifier | MGI:3053118 | Allele Type | Transgenic |
Attribute String | Dominant negative, Inducible, Inserted expressed sequence | Gene | Tg(tetO-Jun)5Nes |
Strain of Origin | FVB | Induced With | doxycycline/tetracycline |
Is Recombinase | false | Is Wild Type | false |
molecularNote | A truncated dominant negative form of the Jun transcription factor is expressed by this transgene. Transcription is directed by a tetracycline-responsive promoter element (TRE). When bred with another transgenic mouse expressing tetracycline-controlled transactivator protein (tTA) to create a bitransgenic animal, Fosb expression can be negatively regulated with the tetracycline analog, doxycycline. |