| First Author | Chen WV | Year | 2017 |
| Journal | Science | Volume | 356 |
| Issue | 6336 | Pages | 406-411 |
| PubMed ID | 28450636 | Mgi Jnum | J:242975 |
| Mgi Id | MGI:5907383 | Doi | 10.1126/science.aal3231 |
| Citation | Chen WV, et al. (2017) Pcdhalphac2 is required for axonal tiling and assembly of serotonergic circuitries in mice. Science 356(6336):406-411 |
| abstractText | Serotonergic neurons project their axons pervasively throughout the brain and innervate various target fields in a space-filling manner, leading to tiled arrangements of their axon terminals to allow optimal allocation of serotonin among target neurons. Here we show that conditional deletion of the mouse protocadherin alpha (Pcdhalpha) gene cluster in serotonergic neurons disrupts local axonal tiling and global assembly of serotonergic circuitries and results in depression-like behaviors. Genetic dissection and expression profiling revealed that this role is specifically mediated by Pcdhalphac2, which is the only Pcdhalpha isoform expressed in serotonergic neurons. We conclude that, in contrast to neurite self-avoidance, which requires single-cell identity mediated by Pcdh diversity, a single cell-type identity mediated by the common C-type Pcdh isoform is required for axonal tiling and assembly of serotonergic circuitries. |
