| First Author | Spahn J | Year | 2011 |
| Journal | Am J Pathol | Volume | 179 |
| Issue | 5 | Pages | 2370-81 |
| PubMed ID | 21925469 | Mgi Jnum | J:177370 |
| Mgi Id | MGI:5294866 | Doi | 10.1016/j.ajpath.2011.08.004 |
| Citation | Spahn J, et al. (2011) Ineffective CD8(+) T-cell immunity to adeno-associated virus can result in prolonged liver injury and fibrogenesis. Am J Pathol 179(5):2370-81 |
| abstractText | Chronic viral hepatitis depends on the inability of the T-cell immune response to eradicate antigen. This results in a sustained immune response accompanied by tissue injury and fibrogenesis. We have created a mouse model that reproduces these effects, based on the response of CD8(+) T cells to hepatocellular antigen delivered by an adeno-associated virus (AAV) vector. Ten thousand antigen-specific CD8(+) T cells undergo slow expansion in the liver and can precipitate a subacute inflammatory hepatitis with stellate cell activation and fibrosis. Over time, antigen-specific CD8(+) T cells show signs of exhaustion, including high expression of PD-1, and eventually both inflammation and fibrosis resolve. This model allows the investigation of both chronic liver immunopathology and its resolution. |
