| First Author | Noh KT | Year | 2013 |
| Journal | Biochem Biophys Res Commun | Volume | 431 |
| Issue | 2 | Pages | 348-53 |
| PubMed ID | 23291179 | Mgi Jnum | J:198077 |
| Mgi Id | MGI:5495366 | Doi | 10.1016/j.bbrc.2012.12.093 |
| Citation | Noh KT, et al. (2013) Resveratrol suppresses tumor progression via the regulation of indoleamine 2,3-dioxygenase. Biochem Biophys Res Commun 431(2):348-53 |
| abstractText | This study showed the potential of resveratrol to inhibit the expression and activity of interferon-gamma (IFN-gamma)-induced indoleamine 2,3-dioxygenase (IDO) in bone marrow-derived dendritic cells (BMDCs). The mechanism of suppression was associated with the activity of Janus kinase/signal transducers and activators of transcription (JAK/STAT) and protein kinase Cdelta (PKCdelta). In addition, resveratrol-mediated IDO suppression in IFN-gamma-stimulated BMDCs appears to play a pivotal role in anti-tumor activity through the regulation of CD8(+) T cell polarization and cytotoxic T lymphocyte (CTL) activity. Systemic administration of resveratrol suppressed tumor growth in EG7 thymoma-bearing mice in an IDO-dependent manner. Taken together, resveratrol not only regulates immune response through the regulation of IDO in a JAK/STAT1- and PKCdelta-dependent manner, but also modulates the IDO-mediated immune tolerance in EG7 thymoma. |
