| First Author | van Dinther D | Year | 2018 |
| Journal | Cell Rep | Volume | 22 |
| Issue | 6 | Pages | 1484-1495 |
| PubMed ID | 29425504 | Mgi Jnum | J:270703 |
| Mgi Id | MGI:6278646 | Doi | 10.1016/j.celrep.2018.01.021 |
| Citation | van Dinther D, et al. (2018) Functional CD169 on Macrophages Mediates Interaction with Dendritic Cells for CD8(+) T Cell Cross-Priming. Cell Rep 22(6):1484-1495 |
| abstractText | Splenic CD169(+) macrophages are located in the marginal zone to efficiently capture blood-borne pathogens. Here, we investigate the requirements for the induction of CD8(+) T cell responses by antigens (Ags) bound by CD169(+) macrophages. Upon Ag targeting to CD169(+) macrophages, we show that BATF3-dependent CD8alpha(+) dendritic cells (DCs) are crucial for DNGR-1-mediated cross-priming of CD8(+) T cell responses. In addition, we demonstrate that CD169, a sialic acid binding lectin involved in cell-cell contact, preferentially binds to CD8alpha(+) DCs and that Ag transfer to CD8alpha(+) DCs and subsequent T cell activation is dependent on the sialic acid-binding capacity of CD169. Finally, functional CD169 mediates optimal CD8(+) T cell responses to modified vaccinia Ankara virus infection. Together, these data indicate that the collaboration of CD169(+) macrophages and CD8alpha(+) DCs for the initiation of effective CD8(+) T cell responses is facilitated by binding of CD169 to sialic acid containing ligands on CD8alpha(+) DCs. |
