| First Author | Knudson KM | Year | 2013 |
| Journal | J Immunol | Volume | 191 |
| Issue | 12 | Pages | 5797-801 |
| PubMed ID | 24244018 | Mgi Jnum | J:207112 |
| Mgi Id | MGI:5554477 | Doi | 10.4049/jimmunol.1300905 |
| Citation | Knudson KM, et al. (2013) Cutting edge: The signals for the generation of T cell memory are qualitatively different depending on TCR ligand strength. J Immunol 191(12):5797-801 |
| abstractText | CD8 T cell memory critically contributes to long-term immunity. Both low- and high-affinity TCR signals are able to support the differentiation of memory CD8 T cells. However, it is unclear whether the requirements for memory development change when TCR signal strength is altered. To gain further insight into this question, we used a TCRbeta transmembrane domain mutant model that is defective in the generation of memory in response to high-affinity ligands. Surprisingly, lowering TCR signal strength, by stimulation with low-affinity ligands, resulted in normal memory development. Restoration of memory correlated with recovery of TCR-dependent NF-kappaB signaling. Thus, these data provide novel evidence that the requirements for memory are qualitatively different depending on TCR signal strength. |
