| First Author | Gérard A | Year | 2013 |
| Journal | Nat Immunol | Volume | 14 |
| Issue | 4 | Pages | 356-63 |
| PubMed ID | 23475183 | Mgi Jnum | J:194908 |
| Mgi Id | MGI:5475047 | Doi | 10.1038/ni.2547 |
| Citation | Gerard A, et al. (2013) Secondary T cell-T cell synaptic interactions drive the differentiation of protective CD8(+) T cells. Nat Immunol 14(4):356-63 |
| abstractText | Immunization results in the differentiation of CD8(+) T cells, such that they acquire effector abilities and convert into a memory pool. Priming of T cells takes place via an immunological synapse formed with an antigen-presenting cell (APC). By disrupting synaptic stability at different times, we found that the differentiation of CD8(+) T cells required cell interactions beyond those made with APCs. We identified a critical differentiation period that required interactions between primed T cells. We found that T cell-T cell synapses had a major role in the generation of protective CD8(+) T cell memory. T cell-T cell synapses allowed T cells to polarize critical secretion of interferon-gamma (IFN-gamma) toward each other. Collective activation and homotypic clustering drove cytokine sharing and acted as regulatory stimuli for T cell differentiation. |
