| First Author | Taraban VY | Year | 2004 |
| Journal | J Immunol | Volume | 173 |
| Issue | 11 | Pages | 6542-6 |
| PubMed ID | 15557144 | Mgi Jnum | J:94377 |
| Mgi Id | MGI:3512659 | Doi | 10.4049/jimmunol.173.11.6542 |
| Citation | Taraban VY, et al. (2004) Cutting Edge: A critical role for CD70 in CD8 T cell priming by CD40-licensed APCs. J Immunol 173(11):6542-6 |
| abstractText | The CD154/CD40 interaction is an important pathway of CD4 T cell help for CD8 T cell responses. In this study, we address the role of CD70, a member of the TNF superfamily and the ligand for the T cell costimulatory receptor CD27, in CD40-mediated priming of CD8 T cells. Using an agonistic anti-CD40 mAb to mimic the CD154/CD40 interaction we demonstrate that the priming of OT-I TCR transgenic or endogenous mouse OVA-specific CD8 T cells is critically dependent on CD70/CD27 interaction. CD70 blockade inhibited CD40-mediated clonal expansion of CD8 T cells and reduced the number of memory CD8 T cells generated. Furthermore, CD70 blockade during the initial priming of CD8 T cells inhibited the ability of memory CD8 T cells to expand in response to a second encounter with Ag. Our data indicate that CD70 expression on APCs plays a key role in CD40-dependent CD8 T cell responses. |
