| First Author | Gracias DT | Year | 2013 |
| Journal | Nat Immunol | Volume | 14 |
| Issue | 6 | Pages | 593-602 |
| PubMed ID | 23603793 | Mgi Jnum | J:197354 |
| Mgi Id | MGI:5492210 | Doi | 10.1038/ni.2576 |
| Citation | Gracias DT, et al. (2013) The microRNA miR-155 controls CD8(+) T cell responses by regulating interferon signaling. Nat Immunol 14(6):593-602 |
| abstractText | We found upregulation of expression of the microRNA miR-155 in primary effector and effector memory CD8(+) T cells, but low miR-155 expression in naive and central memory cells. Antiviral CD8(+) T cell responses and viral clearance were impaired in miR-155-deficient mice, and this defect was intrinsic to CD8(+) T cells, as miR-155-deficient CD8(+) T cells mounted greatly diminished primary and memory responses. Conversely, miR-155 overexpression augmented antiviral CD8(+) T cell responses in vivo. Gene-expression profiling showed that miR-155-deficient CD8(+) T cells had enhanced type I interferon signaling and were more susceptible to interferon's antiproliferative effect. Inhibition of the type I interferon-associated transcription factors STAT1 or IRF7 resulted in enhanced responses of miR-155-deficient CD8(+) T cells in vivo. We have thus identified a previously unknown role for miR-155 in regulating responsiveness to interferon and CD8(+) T cell responses to pathogens in vivo. |
