| Primary Identifier | MGI:3054014 | Allele Type | Transgenic |
| Attribute String | Humanized sequence, Inserted expressed sequence | Gene | Tg(Mt1-RET)192Ina |
| Strain of Origin | (BALB/c x C57BL/6) X BALB/c | Is Recombinase | false |
| Is Wild Type | false |
| description | Sublines 192A, 192B and 192C were derived by crossing early descendants of female founder 192, on a mixed BALB/c and C57BL/6 background, to C57BL/6, (BALB/c x C57BL/6)F1 or BALB/c mice, respectively, then intercrossing the progeny. Other founder lines were 108, 207, 242, 301, 304 and 319. |
| molecularNote | The transgene comprises the cDNA encoding the human ret proto-oncogene driven by the mouse metallothionein 1 promoter/enhancer and followed by a segment of the simian virus 40 (SV40) genome containing a splice signal, a polyadenylation signal and 3' flanking sequence. Northern blot analysis revealed high levels of transgene expression in tumors and varying levels in melanin-producing cells of other tissues in mice of this line, including skin, muscle and Harderian glands. |
