| First Author | Ushiki-Kaku Y | Year | 2013 |
| Journal | Microbiol Immunol | Volume | 57 |
| Issue | 11 | Pages | 792-6 |
| PubMed ID | 24117858 | Mgi Jnum | J:278368 |
| Mgi Id | MGI:6323295 | Doi | 10.1111/1348-0421.12105 |
| Citation | Ushiki-Kaku Y, et al. (2013) Different antigenicities of the N-terminal region of cellular and scrapie prion proteins. Microbiol Immunol 57(11):792-6 |
| abstractText | Limited information is available about conformational differences between the abnormal isoform of prion protein (PrP(Sc) ) and cellular prion protein (PrP(C) ) under native conditions. To clarify conformational differences between these two isoforms, PrP-deficient mice were immunized with brain homogenates of normal and scrapie-infected animals. All mice generated anti-PrP antibodies. Peptide array analysis of these serum samples revealed a distinctive epitope of PrP(Sc) consisting of QGSPGGN (PrP41-47) at the N-terminus. This study demonstrated a conformational dissimilarity at the N-terminus between PrP(Sc) and PrP(C) , a finding that may provide novel information about conformational features of PrP(Sc) . |
