| First Author | Dallmann R | Year | 2007 |
| Journal | Behav Brain Res | Volume | 180 |
| Issue | 2 | Pages | 197-202 |
| PubMed ID | 17459494 | Mgi Jnum | J:121953 |
| Mgi Id | MGI:3712695 | Doi | 10.1016/j.bbr.2007.03.006 |
| Citation | Dallmann R, et al. (2007) Non-photic phase resetting of Dexras1 deficient mice: a more complicated story. Behav Brain Res 180(2):197-202 |
| abstractText | Recently, it has been reported that mice deficient for Dexras1 have a diminished phase-shifting response to photic stimuli but an enhanced response to non-photic stimuli; the latter is of additional interest in that mice generally show relatively weak and unreliable responses to non-photic events. Therefore, in situations in which both photic and non-photic stimuli are present, control of circadian rhythms, relative to wild-types, should tip toward non-photic stimuli in Dexras1(-/-) mice. However, we detected no differences in an experiment in which photic and non-photic entraining agents were presented 180 degrees out of phase, i.e. were in conflict with each other. Furthermore, Dexras1(-/-) and wild-type mice did not differ in non-photic phase shifting to a pulse of confinement in a novel running wheel. Suppression of locomotion by light (masking effect) did not differ between the genotypes, indicating that the photoreceptor input to the non-image forming system is intact. The circadian phenotype of Dexras1(-/-) mice appears to be more complicated than previously thought. |
