| First Author | Xue HH | Year | 2007 |
| Journal | Immunity | Volume | 26 |
| Issue | 4 | Pages | 421-31 |
| PubMed ID | 17442597 | Mgi Jnum | J:123578 |
| Mgi Id | MGI:3718846 | Doi | 10.1016/j.immuni.2007.03.010 |
| Citation | Xue HH, et al. (2007) The transcription factor GABP is a critical regulator of B lymphocyte development. Immunity 26(4):421-31 |
| abstractText | GA binding protein (GABP) is a ubiquitously expressed Ets-family transcription factor that critically regulates the expression of the interleukin-7 receptor alpha chain (IL-7Ralpha) in T cells, whereas it is dispensable for IL-7Ralpha expression in fetal liver B cells. Here we showed that deficiency of GABPalpha, the DNA-binding subunit of GABP, resulted in profoundly defective B cell development and a compromised humoral immune response, in addition to thymic developmental defects. Furthermore, the expression of Pax5 and Pax5 target genes such as Cd79a was greatly diminished in GABPalpha-deficient B cell progenitors, pro-B, and mature B cells. GABP could bind to the regulatory regions of Pax5 and Cd79a in vivo. Thus, GABP is a key regulator of B cell development, maturation, and function. |
